When: Tuesday, May 13, 11:00 a.m.

Where: Conference RoomMellon Institute

Trey Ideker, Associate Professor
Department of Bioengineering
Universty of California, San Diego

Joint CMU-Pitt Ph.D. Program in
Computational Biology Seminar

Abstract:
Physical and genetic mapping data have become as important to Network Biology as they were to the Human Genome Project. Physical interaction maps are being constructed through systematic measurements of protein-protein, protein-DNA, and protein-small molecule interactions. Genetic interaction maps are being generated by large-scale screening of synthetic-lethals and epistasis, by multipoint gene association studies, and by mapping the effects of natural and prescribed genetic variations on gene expression. We are working on ways of integrating physical and genetic interaction maps to assemble models of gene regulatory pathways. These efforts face several challenges, including: increasing the coverage of each type of network; establishing methods to assemble individual interaction measurements into contiguous pathway models; and annotating these pathways with detailed functional information. Efforts in each of these areas will be described. Using integrative tools, we are constructing network models to explain the physiological response of yeast to DNA damaging agents.

Faculty Host: Ziv Bar-Joseph

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